The statistical distribution of nucleic acid similarities

The statistical distribution of nucleic acid similarities.

All pairs of a large set of known vertebrate DNA sequences were searched by computer for most similar segments. Analysis of this data shows that the computed similarity scores are distributed proportionally to the logarithm of the product of the lengths of the sequences involved. This distribution is closely related to recent results of Erdos and others on the longest run of heads in coin tossi...

On the statistical significance of nucleic acid similarities

When evaluating sequence similarities among nucleic acids by the usual methods, statistical significance is often found when the biological significance of the similarity is dubious. We demonstrate that the known statistical properties of nucleic acid sequences strongly affect the statistical distribution of similarity values when calculated by standard procedures. We propose a series of models...

The nucleic acid of African Horse-Sickness Virus

Statistical characterization of nucleic acid sequence functional domains.

It has long been recognized that various genome classes were distinguishable on the basis of base composition and nearest neighbor frequencies. In addition Grantham et al. (8) have recently presented evidence that these distinctions are preserved at the level of codon usage. As discussed in this report it is now clear that these and related statistics can uniquely characterize the various funct...

Some statistical inferences on the upper record of Lomax distribution

In this paper, we investigate some inferential properties of the upper record Lomax distribution. Also, we will estimate the upper record of the Lomax distribution parameters using methods, Moment (MME), Maximum Likelihood (MLE), Kullback-Leibler Divergence of the Survival function (DLS) and Baysian. Finally, we will compare these methods using the Monte Carlo simulation.